Technology at TruDiagnostic:
Proteomics
Technology at TruDiagnostic:
Proteomics
Proteomics
The SEER Proteograph is designed for unbiased, deep, and rapid proteomic analysis at scale. Data is generated by liquid chromatography-mass spectrometry (LC-MS).
Whether you seek to survey thousands of human plasma proteins and discover new insights into the protein makeup of your sample or to dive into the biological meaning of your results by quantifying protein abundance differences between sample conditions, protein-protein interactions, and functional enrichment, our proteograph analysis delivers quantitative, accurate, precise, and reproducible data for proteome studies of any size.
Sample Requirements:
200 microliters of serum plasma in an EDTA tube.
Turnaround Time:
14 working days.
Why do we use the Seer Proteograph?
Coverage
Our Proteograph analysis offers a 4-5x increase in protein count increase compared to traditional targeted proteomic analysis methods
Quantify protein variants better than targeted approaches.
Proteome Depth
This method has demonstrated an order of magnitude gain in median depth of coverage: 2x higher precision, 2.5x protein identifications and significant improvement in throughput compared to a conventional deep workflow.
This method identifies 30% more Cytokines when compared to large scale proteome studies which rely on extensive depletion and fractionation.
Concentration
Unbiased nanoparticle based enrichment combined with highest mass spectrometry based proteomics performance delivers unprecedented proteome depth as nanoparticles compress dynamic range of protein abundance. This enables wide concentration range evaluation.
Peptides
This method increases the quantification of peptides. It’s not limited to larger proteins.
Unlike targeted approaches, peptide level quantitation allows for the distinction between proteoforms and identification of post-translational modifications such as phosphorylation, glycosylation, acetylation and more.
Sensitivity
Proteograph technology significantly boosts sensitivity to detect low abundant proteins compared to workflows with and without antibody based depletion.
Tissues
Tackle large cohorts of challenging clinical samples, such as plasma, urine and cerebrospinal fluid, supporting biomarker discovery and identification of novel targets, and walk away with a robust and high throughput analysis.
TruDiagnostic, alongside Harvard
Has already generated the third largest dataset on proteomics & aging.
Working with our Proteograph means you’ll also have access to an analysis suite of software. This suite offers an easy-to-use, seamlessly integrated way to generate insights from data collected.